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James Bonsack, an avid craftsman, in 1881 created a machine that revolutionized cigarette production

10.1038/nm.2736 57 JinS

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The majority of participants among non-current e-cigarette users at baseline had never used other tobacco products (90.9%), were male (77.0%), were senior high school students (85.2%), had their fathers highest education level above senior high school (50.5%), had their mothers ethnicity being Han Chinese (81.6%), had their parents working full-time (91.5%), and lived with parents or extended family (63.4%)

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A study conducted in 2001 found that testosterone levels in men who smoked were actually higher than those who had never smoked (1)