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Description
More than 7 million of those deaths are the result of direct tobacco use while around 1.2 million are the result of non-smokers being exposed to second-hand smoke.

PMID 29879097

Chronic exposure to e-cigarettes elevates CYP2A5 activity, protein expression, and cotinine-induced production of reactive oxygen species in mice
Aspects of the oxidative metabolism of nicotine
However, a majority of e-cigarette users were still using e-cigarettes at the one-year follow-up

FDA almost always returned to inspect retailers where it found violations within 12 months
