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Critics of the product have argued that flavored e-cigarettes made by companies like Juul are designed to appeal to teens directly

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( B ) The CR concentration was significantly elevated in tumor ( n = 80) compared with nontumor ( n = 67) lung tissue

[xvi] Nicotine is the active ingredient in tobacco

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The reduced risk may be related to tobacco smoke compounds in glutathione S-transferase (GST) activity, which is involved in the nicotine detoxification pathway (Pachauri and Flora, 2013)