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On closer inspection, however, Rolfe discovered that the plant lacked the characteristics of the popular Spanish tobacco

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Neonatal abstinence syndrome may occur in 40 to 70 percent of methadone-exposed infants and may be more protracted than with heroin exposure (Cleary, 2011

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This variation between studies may be due to the different puff routines used to generate the tobacco smoke (HCI vs ISO), aging of smoke particles over the puff routine (4 vs 8 mins) and dilution ratios in the smoke bags (75 vs 33)