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The induction of stemness in lung cancer, associated with e-cigarette use, was mediated through upregulation of a stemness marker SRY (sex determining region Y)-box 2 ( Sox2) , a gene that is highly expressed in stem cells and responsible for self-renewal along with the Yes associated protein 1/ E2F transcription factor 1/Octamer-binding transcription factor 4 ( Yap1 /E2F1/ Oct4) signaling axis [26]

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I can wake up at one o'clock in the morning, have anxiety, be depressed and go down to the local shop, the 24-hour petrol station and purchase cigarettes.' It's just a quick fix, just like alcohol." Targeting tobacco, not people The proposed policies - especially denicotisation and the so-called Smokefree generation - have never been implemented anywhere

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