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We reviewed the data sets for the antihypertensive medications, and the patient was considered as using antihypertensive medication if we found a record of any angiotensinconverting enzyme inhibitors, angiotensin receptor blockers, direct renin inhibitors, beta-blockers, calcium-channel blockers, alpha-blockers, diuretics, or direct-acting vessel dilators for at least 28 consecutive days

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Also, overactivation of the local RAAS as a result of increased ACE expression (Silva et al., 2020), and smoking-related OxS and inflammation (Plekowska et al., 2020) were found to play important roles in the pathogenesis of the disease