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BPDE undergoes chemical reactions with DNA and can turn on or off certain genes which alters protein production or the ability for DNA to duplicate properly

Among the 36 selected outcomes, 8 had strong-to-very-strong evidence of an association with smoking, 21 had weak-to-moderate evidence of association and 7 had no evidence of association

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Svartberg J, Jorde R (2007) Endogenous testosterone levels and smoking in men