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We used a combination of various medical subject headings (MeSH) terms and keywords, and the detailed search strategies for different databases are presented in Supplementary file Material 1

For a deeper side-by-side on where Darkside sits against its closest rival, our breakdown of Musthave versus Darkside covers the leaf processing and buzz differences in detail, and our roundup of the best Musthave flavors covers the other side of that matchup
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The sensitivity analysis data for tolerant users are additionally shown in Figure 13 based on the ratio between no-tolerance and high tolerance dosage as shown in Table 2 27,37,42,43,44,45,46,47,48,49,50,51,52,53,54

Separately, smoking and high blood pressure increase the risk of heart attack and stroke

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