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While p53 exerts antioxidant effects by upregulating several antioxidant genes, such as glutathione peroxidase 1 ( Gpx1 ) and glutaredoxin 3 ( Grx3 ), or repressing the expression of dcyclooxygenase-2 ( Cox2 ) and nitric oxide synthase 2 ( Nos2 ) ( Tigar expression suppresses phosphofructokinase-1 activity and glucose 6-phosphate dehydrogenase (G6PD) activity, resulting in the shutdown of the glycolysis pathway without activating the pentose phosphate pathway, ultimately leading to testicular germ cell apoptosis and infertility ( On the other hand, p53 is sensitive to redox conditions

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Nicksic NE, Snell LM, Barnes AJ

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1992 IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans