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11 Nicotine stimulated migration, proliferation, and tube formation of endothelial cells in vitro , all of which are major steps of angiogenesis

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Menthol enhances the effects of nicotine on the brain and can make tobacco products even more addictive

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Consistent with severely diminished Th1 cytokine production, continuous cigarette smoke exposure substantially inhibited the ability of lung mononuclear cells to produce nitric oxide, thereby diminishing the amount of bactericidal products in the lung and dampening anti-bacterial host defense responses