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Clearance of nicotine is through the liver, primarily by C-oxidation via CYP2A6 metabolizing enzymes, which metabolize nicotine to cotinine

Prineas RJ, Crow RS, Blackburn H: The Minnesota Code Manual of Electrocardiographic Findings: standards and procedures for measurement and classification

What he told doctors shocked them: The boy was vaping when, without warning, his e-cigarette exploded in his face

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and Kirstein, C.L., "Fetal and maternal brain and plasma levels of cocaine and benzoylecgonine following chronic subcutaneous administration of cocaine during gestation in rats," Psychopharmacology 97: 427-431, 1989a

So is this normal