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However, studies showed that KO mice lacking the 2 subtype of nAChRs showed normal levels of anxiety in EPM as well as the light/dark box and mirrored chamber tasks [254], which suggests that 2-containing nAChRs may be required for the effects of nicotine on anxiety but may not be directly involved in anxiety

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[66] Motives may be broken and recombined to form melodies

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