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doi:10.1007/BF00316466

It can cause dry eye irritation, redness, and elevated long-term risk for conditions such as age-related macular degeneration

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Additionally, as creatinine is filtered and excreted by the kidneys, it has a strong physiological association with renal function

Over time we may adapt our expectations of social contact, and while not condoning this as a solution, Weiss (1973) noted that lonely people may "change their standards for appraising their situations and feelings, and, in particular, that standards might shrink to conform more closely to the shape of bleak reality." 7.1.2 Task Choice