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When inflammation occurs, multiple inflammatory signaling pathways are activated, such as p38 MAP kinase (p38 MAPK), phosphatidylinositol-3-kinase (PI3K), and janus kinase/signal transducer and activator of transcription (JAK/STAT) [103]

The data available in this study cannot provide an explanation of this outcome but it does suggest that future studies should not compare smokers with non-smokers but that gender comparisons should be stratified by level of tobacco consumption

In dependent smokers, the urge to smoke cigarettes correlates with a low blood nicotine level, as though smoking were a means to achieve certain nicotine level, reap the rewarding feeling associated with nicotine and avoid withdrawals [22]

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