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Abbreviations ACTA2+ actin alpha 2 ADMA asymmetric dimethylarginine AHA American Heart Association AT alpha1-antitrypsin AT-LDL alpha1-antitrypsin low-density lipoprotein Bupropion SR bupropion sustained-release CAD coronary artery disease CBs cigarette butts CDC Centers for Disease Control and Prevention CNRT combined nicotine replacement therapy CNS central nervous system CO carbon monoxide CRLF1 cytokine receptor-like factor-1 CVD cardiovascular disease DAMPs damage-associated molecular patterns EC endothelial cells E-cigarette electronic cigarette ENDS electronic nicotine delivery system eNOS endothelial nitric oxide synthase ENSP European Network for Smoking and Tobacco Prevention ET-1 endothelin 1 FCTC Framework Convention on Tobacco Control FDA Food and Drug Administration GSDMD Gasdermin D-mediated pyroptosis H 2 O 2 hydrogen peroxide ICAM-1 intercellular adhesion molecule-1 IL interleukin JACC Journal of American College of Cardiology LDL low density lipoprotein MOMP mitochondrial outer membrane permeabilization MRI magnetic resonance imaging MS mainstream smoke mtDNA mitochondrial deoxyribonucleic acid NADPH nicotinamide adenine dinucleotide phosphate hydrogen NCI National Cancer Institute NHIS National Health Interview Survey NHS National Health Service NNTCQ National Network of Tobacco Cessation Quitlines NO nitric oxide NO 2 nitrogen dioxide NRT nicotine replacement therapy NYTS Nicotine Youth Tobacco Survey O 2 superoxide ONOO peroxynitrite anion OSH Office on Smoking and Health PAD peripheral arterial disease PAF population-attributable fraction PAHs polycyclic aromatic hydrocarbons ROS reactive oxygen species SHS second-hand smoke SMART sequential multiple assignment randomized trial SS side-stream smoke STING stimulator of interferon genes TAR total aerosol residue TLR toll-like receptor VCAM-1 vascular cell adhesion molecule-1 VSMC vascular smooth muscle cells VWF von Willebrand factor WHO World Health Organization Competing Interests The authors have no competing interests to declare

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