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Step 2: Position one hand firmly on the bottle to hold it steady

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Patients experience limb heaviness, reduced mobility, recurrent infections (cellulitis), and significant psychosocial burden

They were randomized to receive either PIO (in a daily dose of 15 mg) or placebo for 24 weeks, followed by a 24-week PIO extension for those who had completed the main study

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Whether patients haven't yet reached their weight loss goals on lower-dose Wegovy injectables, or they simply have a more significant amount of weight to lose, the 21% weight loss demonstrated in the STEP UP trial, if all patients stayed on treatment, shows what's possible with this new dose, and that's an opportunity we're excited to provide," said Ed Cinca, senior vice president, Marketing & Patient Solutions at Novo Nordisk