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It is considered a more accessible and patientadministered option, though highquality evidence for its specific efficacy in nociplastic pain requires further substantiation [409, 410]

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Moreover, folate and SAM levels were significantly higher, while HCY, A 40 , presenilin 1-mRNA (PS1, important role in A generation), and TNF-mRNA levels were lower in folate-supplemented individuals [309]

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