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Traditionally, the state has required cigarette and tobacco product licenses for certain businesses, such as wholesalers and vending machine operators, at no cost from the South Carolina Department of Revenue

Next Generation Lab has also trademarked its synthetic nicotine as Pharmanic, a nod to the pharmaceutical industrys interest in the substance

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Compliance with these evolving regulations requires significant investment in research, product testing, and documentation, creating financial and operational burdens for both large corporations and smaller players

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Despite the issues with the regulatory landscape, the shift to modern tobacco products and the digitalization of distribution channels have provided avenues of growth