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can chewing tobacco increase cholesterol Most products, including e-cigarettes, contain nicotine, a chemical that harm the heart, brain and whole body. As with other addictive products, using a nicotine product builds tolerance, leading to more Correlation between smokeless tobacco (Gutkha)
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J Vasc Surg 1996, 24:927-934 [DOI] [PubMed] [Google Scholar] 25.Conklin BS, Zhao W, Zhong DS, Chen C: Nicotine and cotinine up-regulate vascular endothelial growth factor expression in endothelial cells

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Additionally, nicotine may interact with medications such as benzodiazepines and birth control pills, leading to unintended complications

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