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Ultrafine particles have been transferred directly in mice across the bloodbrain barrier and can be distributed via the production of axonal transport or efferent pathways that control inflammation, blood pressure, and metabolism and are regulated by secondary mediators (Figure 2) (162)

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Health effects of VOC gases from wildfire smoke include: Eyes, nose, and throat irritation Respiratory and neural problems Cancer Other Toxic Gases Wildfire smoke can contain other toxic gases including sulfur dioxide (SO), nitrogen dioxide (NO), ozone (O 3 ), and carbon monoxide (CO)

Smokeless tobacco is consumed through the mouth resulting in various types of cancer
