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In the case of amyloid b-protein (A) aggregates and tau hyper-phosphorylation (p-tau) induced pathogenesis, neuronal damage occurred through proinflammatory cytokines (IL1, IL6, and TNF-) or increased activity of CDK5 and P38 [199]

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Dermatol Ther (Heidelb)

Increased epinephrine in your bloodstream elevates your blood pressure and causes your blood vessels to constrict, thus reducing the supply of oxygen to your brain

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Eosinophils can damage the airway epithelium and accelerate airway remodeling by releasing cationic granule proteins, such as eosinophil cationic protein (ECP), that are highly toxic to the respiratory epithelium 16-18