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Aspartate is a limiting metabolite in nucleotide synthesis (32, 33), such that increased aspartate synthesis from elevated tricarboxylic acid and oxidative phosphorylation activity in CR hi NSCLC tumors would support a purine synthesis bias

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After implementation of Australia's pictorial cigarette warnings, focus group research findings concluded that images depicting the health consequences of smoking provided new information beyond what was contained in the text through providing a visual explanation of the negative health effects noted in the text (Ref