cigarette smoke induces cytoplasmic p53 accumulation The role of smoke-induced epigenetic alterations in inflammation | Epigenetics & Chromatin Chronic Cigarette Smoke-Induced Epigenomic Changes

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In conclusion, this review emphasizes the critical role of p53 as a key target in SC prevention, reinforcing the need for further research in this area to prompt the use of p53 chemopreventive agents to counteract the growing number of SC cases

Cruella de Vil is seen using one repeatedly in the 1961 animated Disney film One Hundred and One Dalmatians [23] and in the 1996 remake, in which she is portrayed by Glenn Close

Additionally, the photoprotective effects of 1,25(OH)2D3 was demonstrated in keratinocytes and UV-irradiated skin mice, with a reduction of CPDs and nitric oxide derivatives, and increased p53 expression [140]

Alternatively, p53 can activate autophagy or induce premature senescence of the cells to prevent their oncogenic transformation [14]

[DOI] [PMC free article] [PubMed] [Google Scholar] 98.South A.P., Purdie K.J., Watt S.A., Haldenby S., den Breems N.Y., Dimon M., Arron S.T., Kluk M.J., Aster J.C., McHugh A., et al