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Scientists have known that smoking causes cancer since at least the 1940s, when epidemiological studies showed a clear link between smoking and lung cancer

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Earlier in the 2008, in PC-3M prostate cancer cells, -CBT-diol has been proven to inhibit cell invasion in Matrigel assay, through reducing transepithelial resistance, enhancing paracellular permeability, producing a tighter intercellular barrier and enhancing the cell-cell adhesion (El Sayed et al., 2008)