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When summary-level data from Genome-Wide Association Studies (GWAS) are accessible for both the exposure and outcome of interest, 2SMR is a popular method

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This rush causes the release of a chemical that makes you feel good (dopamine), which is why smoking can be enjoyable or soothing

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Validation & quality assurance The final stages involve human validation, where domain experts manually review filtered data to identify nuances and contextual errors that automated systems might miss