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We will summarize the rise and appeal of these products, review nicotines cardiovascular pharmacology, analyze pouch characteristics relevant to risk, evaluate the existing evidence, identify critical knowledge gaps, and discuss the implications for public health policy and prevention

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Joseph Winter, an anthropologist at the University of New Mexico

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Nicotine and Myocardial Remodeling Cigarette smoking and smokeless tobacco use have been associated with an increased risk of heart failure