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Cox LS, Tiffany ST, Christen AG

Proposes a role for benzo[ a ]pyrene-7,8-diol-9,10-epoxideDNA adducts as causes of mutations found in the TP53 gene in lung cancer

International comparisons Our new study looks at online survey data from more than 4,000 adult smokers in Australia, Canada, Mexico and the U.S

As of 2007, the film had grossed a total of more than $39 million worldwide

Abbreviations AZA: 5-aza-2-deoxycytidine CBP: c-AMP response element binding protein CCAT1: colon cancer-associated transcript-1 COPD: chronic obstructive pulmonary disease COX2: cyclooxygenase-2 COX II: cytochrome C oxidase subunit II CS: cigarette smoke DNMT: DNA methyl transferase ERK: extracellular signal-regulated kinase EZH2: enhancer of zeste homolog 2 HAT: histone acetyltransferase HDAC: histone deacetylase HMT: histone methyltransferase HOTAIR: Hox transcript antisense intergenic RNA IB: inhibitory kappa B IL-1Ra: interleukin-1 receptor antagonist LCPAT1: lung cancer progressionassociation transcript 1 lncRNA: long non-coding RNA MAFbx: muscle atrophy F-box MALAT1: metastasis associated in lung adenocarcinoma transcript 1 MAPK: mitogen-activated protein kinase MSK: mitogen- and stress-activated kinase MUL1: mitochondrial E3 ubiquitin protein ligase 1 MuRF1: muscle ring finger-1 protein NF-B: nuclear factor kappa B NLRP3: Nod-like receptor protein 3 PPAR: peroxisome proliferator-activated receptor PRMT: protein arginine methyltransferase SCAL1: smoke and cancer-associated lncRNA1 SIRT: sirtuin TETs: Tet-eleven translocation proteins UPS: ubiquitinproteasome system USP: ubiquitin-specific protease References Lee J, Taneja V, Vassallo R

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