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[46] Additionally, by blockading FOXO transcription factors and NF-B, the drug modulates SASP and upregulates anti-apoptotic proteins (such as Bcl-2), potentially delaying tissue degeneration and offering anti-aging benefits

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doi: 10.2337/dc11-2113

However, further research is needed to understand their full potential and all details of their mechanism of action, which will enable to expand the therapeutic indications and to determine their optimal use in clinical practice

Both approaches significantly lowered HbA1c levels (weighted mean difference [WMD] 0.75%, 95% CI 0.97 to 0.53) but increased hypoglycemic risk [risk ratio (RR) 7.59, 95% CI 3.3517.17] compared to the unchanged GLP-1RA

Altered zonal expression of the CD26 antigen (dipeptidyl peptidase IV) in human cirrhotic liver