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Nicotine dependence produces withdrawal syndromes (irritability, cognitive disruption, dysphoria), contributing to psychiatric symptom exacerbation and maladaptive coping behaviours

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"Production has been affected at the Nottingham and Nantes sites, which now utilize less than half their manufacturing capacity." Imperial's chief executive, Alison Cooper, added: "These projects are an essential part of securing the sustainable future of the business

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