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Certain patients can develop anal pain, bleeding, and difficulty with bowel movements

and I think that if it were a summer trip (and I didnt have to pack trekking boots and jackets and such), I couldve kept it going for 14 days, says Menon

Retrieved April 10, 2003

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As tolerance develops, you require more of the drug to deliver the initial high, and stopping can lead to withdrawal symptoms

The breakthrough years and the burden of provocation By the mid-to-late 1990s, Charless work had begun to attract serious institutional attention