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If you look only at total testosterone, some human studies say no, and a few even show slightly higher TT in smokers

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"Not just because of the nicotine, but also because it affects your breathing and may increase the risk of sleep disorders, like sleep apnea." Hill also points out that smokers feel the stimulating effect of nicotine differently to other tobacco users

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Fentanyl skin patches are sometimes prescribed for severe pain for use at home