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[19] During the early stages, a combination of perceived pleasure acting as positive reinforcement and desire to respond to social peer pressure may offset the unpleasant symptoms of initial use, which typically include nausea and coughing

PMID 8037390

Differential effects of theaflavin monogallates on cell growth, apoptosis, and Cox-2 gene expression in cancerous versus normal cells

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Since its initial discovery in neuronal cell death, the parthanatos pathway has been implicated in other diseases including diabetes mellitus 24 , pulmonary fibrosis and acute respiratory distress syndrome 21,25,26