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Smoking is one of the most important preventable causes of ill-health and premature death in Scotland

54 The increase in DC numbers after cigarette smoking in humans has led to the hypothesis that these cells play a role in the pathogenesis of COPD (discussed in detail in ref

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Conclusion The analysis in this paper shows that many of the toxins in cigarette smoke increase substantially when additives are put in cigarettes, including the level of TPM, and that, assuming that the toxicological results from Project MIX represent unbiased estimates of the true biological effects, these data show many adverse biological consequences (and that the failure to reach statistical significance was the result of underpowered studies rather than lack of an effect)

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