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Furthermore, the formation of blood vessels in matrigel injected in mice showed -CBT-diol significantly reduced hemoglobin concentration (about 80% reduction) values when compared with vehicle-treated control, indicating -CBT-diol is an effective angiogenesis inhibitor and would be useful to control of VEGF-dependent breast malignancies in the future ( In liver cancer, -CBT-diol inhibited the proliferation of HepG2, SMMC-7721 and HL-7702 tumor cells, reduced the formation of carcinoma cell clones, disrupted the cell cycle by significantly increasing S phase, induced cell apoptosis by regulating p53-PUMA, PI3K-Akt, and IL-1-NF-B-IAP pathways (Yuan et al., 2019)

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PMIs claim that IQOS helps users switch from traditional cigarettes is unsupported by PMIs own research showing that very few users actually completely switched and significant dual use (using both cigarettes and IQOS) remained

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