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[205] Side effects Withdrawal symptoms The CDC recognizes seven common nicotine withdrawal symptoms that people often face when stopping smoking: "cravings to smoke, feeling irritated, grouchy, or upset, feeling jumpy and restless, having a hard time concentrating, having trouble sleeping, feeling hungry or gaining weight, or feeling anxious, sad or depressed." [207] Studies have shown that the use of pharmacotherapies, such as varenicline [208] [209] can be useful in reducing withdrawal symptoms during the quitting process

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Neurosyphilis, as is called when it reaches the brain, is associated with irritability and depression as well as certain cognitive challengesdifficulty concentrating or general confusion, both of which can be categorized as brain fog