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The use of electronic cigarettes increases airway resistance, makes inhalation more difficult, and contributes to the production of highly reactive free radicals, causing an increase in oxidative stress, which in turn is linked to mitochondrial dysfunction and reduced nitric oxide bioavailability [77]

The role of KD in reducing the severity of symptoms in many skin conditions and its beneficial effects on the skin are also gaining recognition (14, 1820)

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Transforming growth factor (TGF) 1 and Smad signalling pathways: a likely key to EMT-associated COPD pathogenesis