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Journal of the American Medical Association 273(13): 1047-1053

Nicotine content averages about 1012mg per cigarette

Cigarette smoke affects digestion through multiple mechanisms: Nicotine stimulates the parasympathetic nervous system Inhaled chemicals create an inflammatory response in the gut Carbon monoxide alters blood flow to digestive organs Smoke exposure changes gut microbiome composition Research shows smoking encourages development of certain bowel diseases while potentially deterring others

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As a result, total nicotine intake over the course of the day can be similarly high or even higher

Smokers are at a significantly higher risk of experiencing strokes due to several factors