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In the era of precision oncology, the biological underpinnings of LCINS necessitate unique diagnostic and treatment paradigms and warrant consideration of this disease as an important and distinct clinical entity

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Forray says the combination approach might be especially good for women, who tend to respond less well than men to treatment with the patch alone (see "Are some people more likely to be hooked than others?" above)

is supported by CNPq 308194/2023-3 and FAPERJ E-26/204.100/2024