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Co-use was relatively stable across the different periods. Writing in the journal of Addictive Behaviors, the researchers said that the evolving trends in use of the two substances could be evidence of a substitution effect amid changing harm perceptions, evolving legislation, and shifting norms. The rising cannabis-only use across groups parallels the expanding state-level recreational cannabis legalization, increasing accessibility and normalization, the paper says

Researchers have been studying the chemical properties of nicotine and nicotine analogs since the beginning of the 1980s

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Email from Egan Reich, US Department of Labor, to Human Rights Watch, November 20, 2013

Upon completing his service in Congress there, Arthur returned home to his family at Middleton Place