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They first go through a review with the FDA
Manufacturers claim that e-cigarettes bypass many of the health risks of tobacco smoking, providing a healthful alternative

Considering the compromised ATP synthesis in the testicular microenvironment, nicotine exposure may hypothetically induce testicular tissue hypoxia and mitochondrial function compensation
Intriguingly, a 2017 systematic review investigating the relationship between smoking and IBS couldnt establish a substantial connection
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PLoS ONE 2015
