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The taste is monotonous: from beginning to end, a cigarette is an average tobacco one, i.e

Continual exposure to cigarette smoke extracts induces tumor-like transformation of human nontumor bronchial epithelial cells in a microfluidic chip

This filter structure: softens the inhale improves smoke distribution reduces sharpness maintains tobacco flavor As a result, the cigarette delivers a more controlled and refined experience, even at higher intensity levels

doi: 10.1093/jmcb/mjz010 16 YaoYZhangQLiZZhangH

This reinforces a potential crosstalk between both transcriptional regulators

doi: 10.1158/1541-7786.MCR-06-0201