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Toxicol Appl Pharmacol 177:4653 Massadeh A, Gharibeh A, Omari K, Al-Momani I, Alomary A, Tumah H, Hayajneh W (2010) Simultaneous determination of Cd, Pb, Cu, Zn, and Se in human blood of Jordanian smokers by ICP-OES

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However, their roots can be traced even further back to indigenous cultures in the Americas, where Native Americans utilized tobacco leaves for both ceremonial and medicinal purposes