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Results from randomized controlled trials and meta-analyses indicate that probiotic supplementation can significantly improve glucose and lipid metabolism, alleviate renal function impairment, and reduce inflammation and oxidative stress levels in DKD patients ( This review aims to systematically elucidate the central hub role of the gut microbiota-enterohepatic axis in dietary nutrient metabolism, with emphasis on exploring the association mechanisms between gut microbiota-mediated amino acid metabolism and DKD, and reviewing research progress on natural bioactive compounds targeting the gut microbiota-enterohepatic axis for DKD intervention