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Tobacco use decreases saliva production and reduces bicarbonate effectiveness, a key acid-neutralizing substance

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The most infamous example of this was so-called Project SCUM (for "Subculture Urban Marketing"), a plan by RJ Reynolds in the mid-1990s to market their Red Kamel brand to gay men in San Francisco's Castro District and homeless people in the city's Tenderloin neighborhood

The germline G660D mutation in the transmembrane domain of HER2 was initially reported in a Japanese family, identified in a female proband with a 1.2 pack-year smoking history and multifocal NSCLC 210