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As well, nicotine downregulates the expression of CCL2 and F4/80 in adipose tissue, which diminishes the infiltration of M1 macrophages [246]

Sources: StatPearls, Ibuprofen British Journal of General Practice , The Dangers of NSAIDs: Look Both Ways Institute for Quality and Efficiency in Health Care, Gastritis Plos One , A Prospective Study of Alcohol Consumption and Smoking and the Risk of Major Gastrointestinal Bleeding in Men Related: