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"I smoke for my mental health," he says," I think it's good for it." Walter Raleigh fell foul of the ferociously anti-smoking King James I who had him executed, not on account of tobacco but a failed expedition to El Dorado: "He took a pipe of tobacco, a little before he went to the scaffold, which some female persons were scandalised at, but I think 'twas well and properly done to settle his spirits," wrote John Aubrey in his diary (admittedly 70 years later)

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Because adolescence represents a vulnerable time of marked neuronal development, it is possible that THC use during this period changes an underlying neurophysiology that makes drugs that are already reinforcing even more rewarding

doi: 10.1111/resp.12949

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