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So fentanyl is highly addictive, more powerful than most addicts know, and it's completely adulterated with no way to control dosages or reactions

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10.1016/j.plaphy.2012.11.011 39 RahmanN.MuhammadI.KhanH.AschnerM.FilosaR.DagliaM.et al (2019)

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Output Filing letter or Refuse to file (RTF) letter Substantive Review : FDA evaluation of the scientific information and data in an application, as well as recommendations from the Tobacco Product Scientific Advisory Committee (TPSAC), public comments, and other information made available to the agency