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Normally, tiny hair-like structures in the airways (called cilia ) help sweep harmful material out of the lungs

One study reported that furan levels tended to be higher in heated tobacco product aerosols compared to smoke from a reference cigarette
Increased saliva cotinine concentrations in smokers during rapid weight loss

Results from sensitivity analyses did not raise major concerns about the main results presented in this paper (see Supplementary Material Appendix D)
Freezing can cause the tobacco to become brittle, and any moisture inside will expand, potentially damaging the integrity of the product
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