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Journal of Pharmacology and Experimental Therapeutics 65(1):89

Given that the average usage time is 30 minutes, we can assume that less nicotine will be released in that time meaning that the nicotine uptake from such a pouch will be somewhat lower

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Theories include: Heat from the cigarette directly burning the skin Changes in the elastic fibres of the skin (elastosis ) Narrowing of blood vessels (vasoconstriction), which reduces blood supply to the skin and can cause changes in skin elastic fibres and loss of collagen Reducing vitamin A levels and moisture of the skin

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Lewis et al