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In summary, nicotine is the active compound, while cotinine is a byproduct of nicotine metabolism that serves as an indicator of nicotine exposure

Celebrity appearances began surfacing, though not yet as pervasive as in later decades

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Engineering metabolism in Nicotiana species: a promising future

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The Legal Attempts to Raise the Smoking and Vaping Age Limit to 21 It began in Needham, Massachusetts, when a bill brought the age at which you could legally buy tobacco, vape juice, and more to 21